R&d Associate, Enzyme Engineering

4 months ago

Cape Town, South Africa Watchmaker Genomics Full time

**Position**:R&D Associate, Enzyme Engineering

**Focus Area**:Enzymology

**Department**: Research and Development

**Position Type**:Full-Time Employee

**Location**:CapeTown, South Africa (onsite)

**Experience**:MSc (or equivalent) in Molecular Biology, Biochemistry, or related discipline + 0-3 years of relevant experience. Or: BSc Honours in biochemistry, molecular biology, or a related discipline + a minimum 2 - 5 years relevant work experience.

**Position summary**

This position offers an opportunity to participate in the development of engineered enzymes that create value for customers in the life sciences and clinical diagnostics markets. There is a strong emphasis on enzyme rational design and directed evolution to achieve these goals. In this collaborative role, you will work closely with various departments, including Applications Development, Computational Biology, Process Development, Marketing, and Customer Support across our global sites.

**Key Responsibilities**
- Design, plan, and perform molecular biology experiments, including plasmid vector design and construction.
- Plan and perform microbiology experiments including: cell transformation and protein expression in shaking flask cultures and bioreactors.
- Plan and perform protein purification experiments including: cell lysis; small scale affinity purification; FPLC-assisted affinity purification.
- Plan and perform protein characterisation experiments including: SDS PAGE and enzyme assays.
- Develop, troubleshoot, and optimize biochemical assays systematically.
- Plan and perform molecular biology experiments including PCR, qPCR and preparation of NGS libraries.
- Document all experimental details in an electronic lab notebook, analyze and interpret data, and present results and project updates to managers and peers.
- Contribute to conceptualizing and inventing technologies for the genomics and molecular diagnostics markets.

**Skills and Requirements**

The following skills and experience are requirements for the position:

- Proficiency in molecular biology techniques, including cloning, PCR, and qPCR.
- Experience in setting up and troubleshooting enzyme assays and in protein expression and purification.
- Familiarity with NGS data analysis is a plus.
- Specific knowledge of DNA- and RNA-modifying enzymes is advantageous.
- Strong interest in protein biochemistry and genomics.
- Demonstrated ability to plan, execute, troubleshoot, and interpret high-quality experiments.
- Excellent organizational skills with meticulous attention to detail.
- Strong interpersonal and communication skills, with the ability to work effectively both independently and as part of a team.
- High level of self-motivation and initiative, with the ability to multitask and perform consistently under pressure.

**Education and Experience**
- MSc in biochemistry, molecular biology, or a related discipline + 0-3 years of relevant experience or BSc Honours in biochemistry, molecular biology, or a related discipline + a minimum 2 - 5 years relevant work experience.

**Application Requirements**
- Letter of motivation (upload where it says cover letter)
- Resume or _Curriculum vitae_, highlighting relevant qualifications and experience

If selected to participate in the interview process, the names and contact information of three professional references who are able to assess your suitability for the position in terms of the specified requirements will be requested.
- **_

**_ WE ARE AN EQUAL OPPORTUNITY/AFFIRMATIVE ACTION EMPLOYER_**
- Watchmaker Genomics is committed to being an equal opportunity employer and creating a culturally diverse environment. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability status, age, or veteran status or any other characteristics as protected by applicable law._
- All applicants will be asked if currently eligible to work in South Africa; and if now or in the future will require visa sponsorship to continue working in South Africa._

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