Research and Development Senior Scientist- Enzyme

7 months ago

Cape Town, South Africa Watchmaker Genomics Full time

**Position**:Research and Development Senior Scientist
- Enzyme Engineering

**Department**: Research and Development

**Position Type**:Full-Time Employee

**Location**:Cape Town, South Africa (onsite)

**Experience**: PhD + 5 years, or MSc + 10 years experience

Pnet Link

**Position description**

**Responsibilities**
- Conceptualise and champion research projects and programmes that align with company strategy and support our commercial objectives.
- Design, plan and perform molecular biology experiments including plasmid vector design and construction.
- Plan and perform microbiology experiments including: cell transformation and protein expression in shaking flask cultures and bioreactors.
- Plan and perform protein purification experiments including: cell lysis; small scale affinity purification; FPLC-assisted affinity purification.
- Plan and perform protein characterisation experiments including: SDS PAGE and enzyme assays.
- Systematically and methodically develop, trouble-shoot and optimise biochemical assays.
- Plan and perform molecular biology experiments including PCR, qPCR and preparation of NGS libraries.
- Accurately document details of all experiments in an electronic lab notebook; meticulously analyse and interpret data; and regularly present results and project status updates to managers and peers for discussion.
- Contribute to conceptualising and inventing technologies for the genomics and molecular diagnostics markets.

**Skills and Requirements**

The following skills and experience are requirements for the position:

- Ability to drive impactful and relevant biotechnology research, with the objective of developing products of practical and commercial value.
- Extensive experience in molecular biology including cloning, PCR and qPCR.
- Experience in setting up and troubleshooting enzyme assays.
- Experience in protein expression and purification.
- Experience in analysing NGS data would be an advantage.
- Experience in computational prediction of enzyme structure would be an advantage.
- Experience in changing protein function through mutagenesis would be an advantage.
- Specific knowledge of DNA- and RNA-modifying enzymes would be an advantage.
- Strong interest in protein biochemistry and genomics.
- Demonstrated ability to plan, execute, troubleshoot, and interpret high quality experiments.
- Track record of successfully proposing and executing research projects.
- Excellent organisational skills and meticulous attention to detail.
- The ability to multitask, perform consistently under pressure and work without supervision.
- Strong interpersonal skills and an ability to work as an effective member of a team, and/or as a leader of a team.
- Excellent written and verbal communication skills.
- Excellent personal task management skills with a high level of self-motivation and initiative.
- A creative and disciplined approach to problem-solving.

**Education and Experience**
- PhD with 3 years of experience or MSc with 10 years of relevant experience in biochemistry, molecular biology, or a related discipline.

**Application Procedure**
- Letter of motivation
- _Curriculum vitae_, highlighting relevant qualifications and experience

If selected to participate in the interview process, the names and contact information of 3 references who are able to assess your suitability for the position in terms of the specified requirements will be requested.
- **_

**_ WE ARE AN EQUAL OPPORTUNITY/AFFIRMATIVE ACTION EMPLOYER_**
- Watchmaker Genomics is committed to being an equal opportunity employer and creating a culturally diverse environment. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability status, age, or veteran status or any other characteristics as protected by applicable law._
- All applicants will be asked if currently eligible to work in South Africa; and if now or in the future will require visa sponsorship to continue working in South Africa._

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