Phd Position in The Clime Group, Faculty of

3 months ago


Cape Town, South Africa Clinical Mycobacteriology and Epidemiology Research Group Full time

**Project title**: Microbiome and metabolomic shifts during drug-resistant tuberculosis treatment

**Duration**: 3 years

**Description**

The Clinical Epidemiology & Mycobacteriology (CLIME) group is seeking to fill an exciting PhD position based in the Division of Molecular Biology & Human Genetics, Stellenbosch University, Cape Town, South Africa.

Antibiotics have a profound impact on the microbiome, yet little is known about their effects in people with tuberculosis (TB; the world's leading infectious cause of death) where hundreds of pills are administered for cure. Antibiotic-mediated microbial disturbances could be linked to poor health outcomes such as post-TB treatment sequalae. This project will evaluate microbiome changes before, during, and after drug-resistant TB treatment, how these changes correspond to pharmacokinetic profiles (a key determinant of long-term cure), how specific taxa correlate with microbially-derived metabolites (short-chain fatty acids), and the microbiome’s association with outcomes.

**Requirements**:
1. Masters’ degree in Molecular Biology or a related field with an average of ≥70%

2. Ability to communicate findings to audiences from diverse disciplines

3. Fluency in English

**Recommendations**

1. Proficient in R and/or Python;
2. Leading role in ≥1 article published in an international peer-reviewed journal

3. Evidence of participation in microbiome courses, workshops, or other initiatives

4. Research experience in infectious diseases, especially tuberculosis

Application Deadline: 2024/10/01



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