Post-graduate Research Fellow

2 weeks ago

Cape Town, South Africa AJ Personnel Full time

**Main purpose of the job**:

- Under direct supervision of the study principal investigator(s), to lead the study site teams, manage day-to-day activities of the study, and provide clinical guidance in the management of patients with HIV-associated cryptococcal meningitis participating in the AMBI-ONE study according to the study protocol
- _The applicant will have the opportunity to work in a dynamic, international, and supportive research environment (within the NIHR-funded Global Health Research Group on HIV-Associated Fungal Infections [IMPRINT]) and to shape the conduct of the multi-center AMBI-ONE research study led by Médecins Sans Frontières (MSF)_
- _The successful applicant will be expected to register for a PhD Degree at the University of the Witwatersrand prior to being appointed as a research fellow_

**Location**:

- **Based in Cape Town (Southern Africa Medical Unit, Médecins Sans Frontières office)**:

- **Registered for a PhD at the University of the Witwatersrand in Johannesburg**

**Key performance areas**:

- Research study management_
- Contribute to the development of study documentation including the protocol, patient information sheets, consent forms, CRFs and data capture tools, standard operating procedures, working practice documents, quality assurance and quality control guidelines, and training materials
- Regularly visit the recruiting sites in the Democratic Republic of Congo, Mozambique, and Guinea to prepare for the start of the study, conduct site initiation visits, and monitor progress
- Oversee recruitment of eligible patients according to protocol and ethical requirements
- Conduct a qualitative-methods research sub-study nested within AMBI-ONE
- Maintain close contact with the AMBI-ONE study management group and consult with them on strategic issues that might have any safety or major financial implications for the project. This will include, but not be limited to, the collation of weekly reports of study progress to be shared with the study management group and funders
- Conduct the research study in accordance with GCP regulations and standard operating procedures
- Proactively resolve protocol queries and missing data with the study management group
- Contribute to the analysis, write-up, and dissemination of study findings
- Patient care and screening_
- Contribute to the clinical support of the study participants in collaboration with the on-site clinical teams and the advisory support teams in MSF
- Quality Assurance_
- Monitor and evaluate the quality of care at the study sites and assess findings with the team
- Perform monitoring visits and quality control checks of clinical source notes and CRFs
- Monitor the Study Recruitment/Retention Plan including planning meetings to address challenges of study enrolment, conduct, and participant retention
- Conduct regular site meetings to identify, discuss and solve study queries
- Meet with external Monitors as and when required
- Staff Management_
- Play a supervisory role for the study clinical and nursing teams to ensure that teams adhere to the set standard operating procedures in the conduct of the study and that all staff are fully trained in the SOPs pertaining to their daily work; data collection process is enhanced for quality and with quality control measures in place; recruitment/accrual targets are being met; proper source documentation procedures are followed
- Foster positive working relationships with the wide research team

**Required minimum education and training**:

- **Medical Degree (MBChB, MBBS, MD or equivalent)**:

- **Specialist training in internal medicine (MMed, FCP, MRCP, or equivalent) would be an advantage**:

- **Certification in Good Clinical Practice (GCP)**:

- **Registration with the HPCSA as an independent medical practitioner is not essential**

**Required minimum work experience**:

- **Minimum 4 years of clinical work experience, preferably in an inpatient environment managing people living with HIV and other infectious diseases**

**Academic expectations**:

- Enrol for a full-time PhD at the University of Witwatersrand with regular travel to Johannesburg
- Completion of a PhD thesis based on the AMBI-ONE research project and related sub-studies, in accordance with institutional PhD regulations
- Preparation of scientific reports, conference presentations, and publications
- Contribution to the Institutional teaching program as appropriate to the level of experience

**Essential additional education, work experience, and personal abilities**:

- Comfortable and able to travel to study sites in Guinea, DRC, and Mozambique
- Spoken and written proficiency in English and French; proficiency in Portuguese would be an added advantage
- Experience in the conduct of clinical research and implementation studies
- An ordered and systematic approach to tasks with strict adherence to protocols
- Exceptional planning and organizational skills
- Ability to create and maintain effective

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